SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient
Author(s)
Mendes-Correa, Maria Cassia
Ghilardi, Fabio de Rose
Salomao, Matias Chiarastelli
Villas-Boas, Lucy Santos
Paula, Anderson Vicente de
Type
Journal Article
Abstract
This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset.
Date Issued
2024-01-01
Date Acceptance
2024-03-25
Citation
Revista do Instituto de Medicina Tropical de Sao Paulo, 2024, 66
ISSN
0036-4665
Publisher
Universidade de São Paulo (USP)
Journal / Book Title
Revista do Instituto de Medicina Tropical de Sao Paulo
Volume
66
Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38747849
PII: S0036-46652024000100506
Subjects
Cell culture
Evolution
Immunodeficiency
Infectious Diseases
Life Sciences & Biomedicine
Parasitology
SARS-CoV-2
Science & Technology
Shedding
Tropical Medicine
Publication Status
Published
Coverage Spatial
Brazil
Article Number
e28
Date Publish Online
2024-05-13