CXCR4, the master regulator of neutrophil trafficking in homoeostasis and disease.
File(s)
Author(s)
De Filippo, Katia
Rankin, Sara M
Type
Journal Article
Abstract
BACKGROUND: Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homoeostasis and disease. RESULTS: The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. CONCLUSION: In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homoeostasis and disease. We also discuss the role of CXCR4 in fine-tuning neutrophil responses in the context of inflammation.
Date Issued
2018-11-01
Date Acceptance
2018-04-30
Citation
European Journal of Clinical Investigation, 2018, 48 (S2)
ISSN
0014-2972
Publisher
Wiley
Journal / Book Title
European Journal of Clinical Investigation
Volume
48
Issue
S2
Copyright Statement
© 2018 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor
Wellcome Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29734477
Grant Number
201356/Z/16/Z
Subjects
CXCR4
clearance
mobilization
neutrophils
retention
Publication Status
Published
Coverage Spatial
England
Article Number
e12949
Date Publish Online
2018-05-07