Interaction of the joining region in junctophilin-2 with the L-type Ca2+ channel is pivotal for cardiac dyad assembly and intracellular Ca2+ dynamics
Author(s)
Type
Journal Article
Abstract
Ca2+-induced Ca2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR is disrupted in cardiac hypertrophy and heart failure, which is associated with loss of T-tubules and disruption of cardiac dyads. In these conditions, LTCCs are redistributed from the T-tubules to disrupt CICR. The molecular mechanism responsible for LTCCs recruitment to and from the T-tubules is not well known. JPH (junctophilin) 2 enables close association between T-tubules and the junctional sarcoplasmic reticulum to ensure efficient CICR. JPH2 has a so-called joining region that is located near domains that interact with T-tubular plasma membrane, where LTCCs are housed. The idea that this joining region directly interacts with LTCCs and contributes to LTCC recruitment to T-tubules is unknown.
Date Issued
2021-01-08
Date Acceptance
2020-10-21
Citation
Circulation Research, 2021, 128 (1), pp.92-114
ISSN
0009-7330
Publisher
American Heart Association
Start Page
92
End Page
114
Journal / Book Title
Circulation Research
Volume
128
Issue
1
Copyright Statement
© 2020 American Heart Association, Inc. Gross, Polina, et al. "Interaction of the joining region in junctophilin-2 with the L-type Ca2+ channel is pivotal for cardiac dyad assembly and intracellular Ca2+ dynamics." Circulation research 128.1 (2021): 92-114.
Sponsor
British Heart Foundation
Grant Number
RG/17/13/33173
Subjects
calcium channels
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
heart failure
Hematology
junctophilin
Life Sciences & Biomedicine
Peripheral Vascular Disease
Science & Technology
Publication Status
Published
Date Publish Online
2020-10-23