An input-stage optimized for multi-channel surface electromyography applications has been designed and realized in 0.35 μm CMOS technology. MOS-based pseudo-resistors and MOS-capacitors were utilized at the input AC-coupling stage to minimize chip area. Measured performance and variability results are provided across 20 fabricated channels from five dies. Confirming biological measurements were performed using commercially-available electrodes.Clinical Relevance—The proposed input-stage could be utilized to miniaturize existing desktop-based >128 channel sEMG research setups into wearable products