Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
File(s)d2cc03092f.pdf (1.63 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
Date Issued
2022-09-01
Date Acceptance
2022-08-31
Citation
Chemical Communications, 2022, 58 (58), pp.10933-10936
ISSN
1359-7345
Publisher
Royal Society of Chemistry
Start Page
10933
End Page
10936
Journal / Book Title
Chemical Communications
Volume
58
Issue
58
Copyright Statement
© The Royal Society of Chemistry 2022. This Open Access Article is licensed under a
Creative Commons Attribution 3.0 Unported Licence.
Creative Commons Attribution 3.0 Unported Licence.
License URL
Sponsor
Cancer Research UK
Commission of the European Communities
Engineering and Physical Sciences Research Council
Identifier
http://pubs.rsc.org/en/content/articlehtml/2022/cc/d2cc03092f
Grant Number
25192
840690
EP/R512540/1
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
KINOME
KINASE
COMPLEX
LIGASE
TOOLS
Intercellular Signaling Peptides and Proteins
Protein Kinases
Proteolysis
Tumor Necrosis Factor Ligand Superfamily Member 14
Ubiquitin-Protein Ligases
03 Chemical Sciences
Organic Chemistry
Publication Status
Published
Date Publish Online
2022-09-01