Global disparities in childhood neuroblastoma: trends, burden, and inequities from 1990 to 2021
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Childhood neuroblastoma, a leading cause of cancer-related mortality in young children, accounts for approximately 8%–10% of pediatric cancers1. Originating from neural crest cells of the sympathetic nervous system, these tumors affect primarily children younger than 5 years of age and are often diagnosed in advanced stages, because of their aggressive nature and vague early symptoms2–4. Although advances in diagnostics and multimodal treatment have increased survival in high-income regions, stark disparities in outcomes persist globally. Particularly in low- and middle-income countries, limited access to early detection, specialized care, and essential therapies has contributed to persistent mortality5–8. Using data from the Global Burden of Disease (GBD) Study 2021, we analyzed trends in the incidence, mortality, and disability-adjusted life years (DALYs) attributable to neuroblastoma in children aged 0-14 years across 204 countries from 1990 to 2021, and identified key demographic, regional, and socio-economic factors contributing to the global burden of childhood neuroblastoma.
Date Issued
2025-07-15
Date Acceptance
2025-06-12
Citation
Cancer Biology & Medicine, 2025, 22 (7), pp.1-6
ISSN
2095-3941
Publisher
China Anti-Cancer Association
Start Page
1
End Page
6
Journal / Book Title
Cancer Biology & Medicine
Volume
22
Issue
7
Copyright Statement
©2025 The Authors. Creative Commons Attribution-NonCommercial 4.0 International License
License URL
Publication Status
Published
Article Number
20250163
Date Publish Online
2025-07-30