Ageing as developmental decay: insights from p16(INK4a.)
File(s)
Accepted version
Author(s)
Martin, N
Beach, D
Gil, J
Type
Journal Article
Abstract
The p16(INK4a) cell cycle regulator is one of the best ageing biomarkers because it is suppressed in early embryogenesis and progressively induced during ageing. p16(INK4a) plays a crucial role in key cell fate decisions which contribute to ageing, such as cellular senescence and stem cell dynamics. Detailed examination of the pathways regulating p16(INK4a) expression has revealed an overlap with those regulating early development. We present the hypothesis that ageing might be primarily driven by gradual functional decay of developmental pathways. To support this, we summarise the role of p16(INK4a) in ageing and our current knowledge on p16(INK4a) regulation. The developmental decay hypothesis implies that the much-evidenced damage associated with all aspects of ageing might be secondary to such decay.
Date Issued
2014-12-31
ISSN
1471-4914
Journal / Book Title
Trends Mol Med
Copyright Statement
© 2014 Elsevier Ltd. All rights reserved. NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Molecular Medicine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in TRENDS IN MOLECULAR MEDICINE, (2014) DOI: 10.1016/j.molmed.2014.09.008
Description
13.11.14 KB. Ok to add accepted version to spiral, subject to 12 months embargo.
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/25277993
S1471-4914(14)00145-2