Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria
File(s)
Published version
Accepted version
Author(s)
Valentini, M
Filloux, A
Type
Journal Article
Abstract
The cyclic-di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers. This review provides an up-to-date compendium of c-di-GMP pathways connected to biofilm formation, biofilm-associated motilities and other functionalities in the ubiquitous and opportunistic human pathogen Pseudomonas aeruginosa. This bacterium is frequently adopted as model organism to study bacterial biofilm formation. Importantly, its versatility and adaptation capabilities are linked with a broad range of complex regulatory networks, including a large set of genes involved in c-di-GMP biosynthesis, degradation and transmission.
Date Issued
2016-04-21
Date Acceptance
2016-04-21
Citation
Journal of Biological Chemistry, 2016, 291 (24), pp.12547-12555
ISSN
1083-351X
Publisher
American Society for Biochemistry and Molecular Biology
Start Page
12547
End Page
12555
Journal / Book Title
Journal of Biological Chemistry
Volume
291
Issue
24
Copyright Statement
© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Made available under a Creative Commons CC-BY license.
License URL
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/L007959/1
Subjects
Pseudomonas aeruginosa (P. aeruginosa)
antibiotic resistance
biofilm
cyclic di-GMP (c-di-GMP)
signaling
Biochemistry & Molecular Biology
06 Biological Sciences
11 Medical And Health Sciences
03 Chemical Sciences
Publication Status
Published