Repository logo
  • Log In
    Log in via Symplectic to deposit your publication(s).
Repository logo
  • Communities & Collections
  • Research Outputs
  • Statistics
  • Log In
    Log in via Symplectic to deposit your publication(s).
  1. Home
  2. Faculty of Engineering
  3. Faculty of Engineering
  4. Unannounced meals in the artificial pancreas: detection using continuous glucose monitoring
 
  • Details
Unannounced meals in the artificial pancreas: detection using continuous glucose monitoring
File(s)
sensors-18-00884-v2.pdf (1.13 MB)
Published version
Author(s)
Ramkissoon, Charrise M
Herrero, Pau
Bondia, Jorge
Vehi, Josep
Type
Journal Article
Abstract
The artificial pancreas (AP) system is designed to regulate blood glucose in subjects with type 1 diabetes using a continuous glucose monitor informed controller that adjusts insulin infusion via an insulin pump. However, current AP developments are mainly hybrid closed-loop systems that include feed-forward actions triggered by the announcement of meals or exercise. The first step to fully closing the loop in the AP requires removing meal announcement, which is currently the most effective way to alleviate postprandial hyperglycemia due to the delay in insulin action. Here, a novel approach to meal detection in the AP is presented using a sliding window and computing the normalized cross-covariance between measured glucose and the forward difference of a disturbance term, estimated from an augmented minimal model using an Unscented Kalman Filter. Three different tunings were applied to the same meal detection algorithm: (1) a high sensitivity tuning, (2) a trade-off tuning that has a high amount of meals detected and a low amount of false positives (FP), and (3) a low FP tuning. For the three tunings sensitivities 99 ± 2%, 93 ± 5%, and 47 ± 12% were achieved, respectively. A sensitivity analysis was also performed and found that higher carbohydrate quantities and faster rates of glucose appearance result in favorable meal detection outcomes.
Date Issued
2018-03-16
Date Acceptance
2018-03-14
Citation
Sensors (Basel, Switzerland), 2018, 18 (3)
URI
http://hdl.handle.net/10044/1/58400
DOI
https://www.dx.doi.org/10.3390/s18030884
ISSN
1424-2818
Publisher
MDPI AG
Journal / Book Title
Sensors (Basel, Switzerland)
Volume
18
Issue
3
Copyright Statement
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29547553
PII: s18030884
Subjects
Unscented Kalman Filter
artificial pancreas
meal detection
physiological models
type 1 diabetes
unannounced meals
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
ARTN 884
About
Spiral Depositing with Spiral Publishing with Spiral Symplectic
Contact us
Open access team Report an issue
Other Services
Scholarly Communications Library Services
logo

Imperial College London

South Kensington Campus

London SW7 2AZ, UK

tel: +44 (0)20 7589 5111

Accessibility Modern slavery statement Cookie Policy

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Cookie settings
  • Privacy policy
  • End User Agreement
  • Send Feedback