Prostate carcinogenesis: inflammatory storms
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory cell recruitment and expansion can ultimately promote DNA double-strand breaks and androgen receptor activation in prostate epithelial cells. The activation of the senescence-associated secretory phenotype fuels further 'inflammatory storms', with free radicals leading to further DNA damage. This drives the overexpression of DNA repair and tumour suppressor genes, rendering these genes susceptible to mutagenic insults, with carcinogenesis accelerated by germline DNA repair gene defects. We provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries.
Date Issued
2020-08
Date Acceptance
2020-04-24
Citation
Nature Reviews Cancer, 2020, 20, pp.455-469
ISSN
1474-175X
Publisher
Nature Research (part of Springer Nature)
Start Page
455
End Page
469
Journal / Book Title
Nature Reviews Cancer
Volume
20
Copyright Statement
© 2020 Springer Nature Limited.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32546840
PII: 10.1038/s41568-020-0267-9
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
TUMOR-INFILTRATING LYMPHOCYTES
ANDROGEN DEPRIVATION THERAPY
HIGH-FAT DIET
SUPPRESSOR-CELLS
CANCER CELLS
CELLULAR SENESCENCE
PARP INHIBITION
NEOANTIGEN LOAD
ADIPOSE-TISSUE
DOUBLE-BLIND
Oncology & Carcinogenesis
11 Medical and Health Sciences
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-06-16