Synthesis and antimicrobial activity of phosphonopeptide derivatives incorporating single and dual inhibitors
File(s)
Published version
OA Location
Author(s)
Type
Journal Article
Abstract
In diagnostic microbiology, culture media are widely used for detection of pathogenic bacteria. Such media employ various ingredients to optimize detection of specific pathogens such as chromogenic enzyme substrates and selective inhibitors to reduce the presence of commensal bacteria. Despite this, it is rarely possible to inhibit the growth of all commensal bacteria, and thus pathogens can be overgrown and remain undetected. One approach to attempt to remedy this is the use of “suicide substrates” that can target specific bacterial enzymes and selectively inhibit unwanted bacterial species. With the purpose of identifying novel selective inhibitors, six novel phosphonopeptide derivatives based on d/l-fosfalin and β-chloro-l-alanine were synthesized and tested on 19 different strains of clinically relevant bacteria. Several compounds show potential as useful selective agents that could be exploited in the recovery of several bacterial pathogens including Salmonella, Pseudomonas aeruginosa, and Listeria.
Date Issued
2020-03-28
Date Acceptance
2020-03-20
Citation
Molecules, 2020, 25 (7), pp.1-25
ISSN
1420-3049
Publisher
MDPI AG
Start Page
1
End Page
25
Journal / Book Title
Molecules
Volume
25
Issue
7
Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.mdpi.com/1420-3049/25/7/1557
Subjects
Organic Chemistry
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
0307 Theoretical and Computational Chemistry
Publication Status
Published online
Date Publish Online
2020-03-28