β-adrenergic receptor responsiveness in aging heart and clinical implications.
File(s)
Author(s)
Type
Journal Article
Abstract
Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called β-adrenergic desensitization ). Adrenergic responsiveness is altered with aging and the age-related changes are limited to the β-adrenergic receptor density reduction and to the β-adrenoceptor-G-protein(s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. Epidemiological studies have shown an high incidence and prevalence of heart failure in the elderly and a great body of evidence correlate the changes of β-adrenergic system with heart failure pathogenesis. In particular it is well known that: (a) levels of cathecolamines are directly correlated with mortality and functional status in heart failure, (b) β1-adrenergic receptor subtype is down-regulated in heart failure, (c) heart failure-dependent cardiac adrenergic responsiveness reduction is related to changes in G proteins activity. In this review we focus on the cardiovascular β-adrenergic changes involvement in the aging process and on similarities and differences between aging heart and heart failure. © 2014 Ferrara, Komici, Corbi, Pagano, Furgi, Rengo, Femminella, Leosco and Bonaduce.
Date Issued
2014-02-12
Start Page
396
Journal / Book Title
Front Physiol
Volume
4
Copyright Statement
Copyright © 2014 Ferrara, Komici, Corbi, Pagano, Furgi, Rengo, Femminella, Leosco
and Bonaduce. This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction
in other forums is permitted, provided the original author(s) or licensor are credited
and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not
comply with these term
and Bonaduce. This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY). The use, distribution or reproduction
in other forums is permitted, provided the original author(s) or licensor are credited
and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not
comply with these term
License URL
Description
17.07.14 KB. Ok to add published version to spiral, OA paper
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/24409150
Coverage Spatial
Switzerland