Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions
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Published version
Author(s)
Otunla, A
Shanmugarajah, K
Davies, Alun
Shalhoub, Joseph
Type
Journal Article
Abstract
Dysregulated lipid metabolism is implicated in the pathophysiology of a range of kidney diseases. The specific mechanisms through which lipotoxicity contributes to acute kidney injury (AKI) remain poorly understood. Herein we review the cardinal features of lipotoxic injury in ischemic kidney injury; lipid accumulation and mitochondrial lipotoxicity. We then explore a new mechanism of lipotoxicity, what we define as “immunometabolic” lipotoxicity, and discuss the potential therapeutic implications of targeting this lipotoxicity using lipid lowering medications.
Date Issued
2024-02-23
Date Acceptance
2024-02-12
Citation
Frontiers in Pharmacology, 2024, 15, pp.1-15
ISSN
1663-9812
Publisher
Frontiers Media S.A.
Start Page
1
End Page
15
Journal / Book Title
Frontiers in Pharmacology
Volume
15
Copyright Statement
© 2024 Otunla, Shanmugarajah, Davies and
Shalhoub. This is an open-access article
distributed under the terms of the Creative
Commons Attribution License (CC BY). The use,
distribution or reproduction in other forums is
permitted, provided the original author(s) and
the copyright owner(s) are credited and that the
original publication in this journal is cited, in
accordance with accepted academic practice.
No use, distribution or reproduction is
permitted which does not comply with these
terms.
Shalhoub. This is an open-access article
distributed under the terms of the Creative
Commons Attribution License (CC BY). The use,
distribution or reproduction in other forums is
permitted, provided the original author(s) and
the copyright owner(s) are credited and that the
original publication in this journal is cited, in
accordance with accepted academic practice.
No use, distribution or reproduction is
permitted which does not comply with these
terms.
License URL
Identifier
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1355674/full
Publication Status
Published
Article Number
1355674
Date Publish Online
2024-02-23