Effect of prednisolone on inflammatory markers in pericardial tuberculosis: A pilot study
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Background: Pericardial disorders are a common cause of heart disease, and the most common cause of pericarditis in developing countries is tuberculous (TB) pericarditis. It has been shown that prednisolone added to standard anti-TB therapy leads to a lower rate of constrictive pericarditis. We conducted a pilot study to evaluate the effect of adjunctive prednisolone treatment on the concentration of inflammatory markers in pericardial tuberculosis, in order to inform immunological mechanisms at the disease site. Methods: Pericardial fluid, plasma and saliva samples were collected from fourteen patients with pericardial tuberculosis, at multiple time points. Inflammatory markers were measured using multiplex luminex analysis and ELISA. Results: In samples from 14 patients we confirmed a strongly compartmentalized immune response at the disease site and found that prednisolone significantly reduced IL-6 concentrations in plasma by 8 hours of treatment, IL-1beta concentrations in saliva, as well as IL-8 concentrations in both pericardial fluid and saliva by 24 hours. Conclusion: Monitoring the early effect of adjunctive immunotherapy in plasma or saliva is a possibility in pericarditis.
Date Issued
2017-11-03
Date Acceptance
2017-10-22
Citation
IJC Heart and Vasculature, 2017, 18, pp.104-108
ISSN
2352-9067
Publisher
Elsevier
Start Page
104
End Page
108
Journal / Book Title
IJC Heart and Vasculature
Volume
18
Copyright Statement
© 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (
http://creativecommons.org/licenses/by/4.0/)
http://creativecommons.org/licenses/by/4.0/)
Publication Status
Published
Date Publish Online
2017-11-03