The L-cell in nutritional sensing and the regulation of appetite
File(s)
Author(s)
Spreckley, E
Murphy, KG
Type
Journal Article
Abstract
The gastrointestinal (GI) tract senses the ingestion of food and responds by signaling to the brain to promote satiation and satiety. Representing an important part of the gut–brain axis, enteroendocrine L-cells secrete the anorectic peptide hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) in response to the ingestion of food. The release of GLP-1 has multiple effects, including the secretion of insulin from pancreatic β-cells, decreased gastric emptying, and increased satiation. PYY also slows GI motility and reduces food intake. At least part of the gut–brain response seems to be due to direct sensing of macronutrients by L-cells, by mechanisms including specific nutrient-sensing receptors. Such receptors may represent possible pathways to target to decrease appetite and increase energy expenditure. Designing drugs or functional foods to exploit the machinery of these nutrient-sensing mechanisms may offer a potential approach for agents to treat obesity and metabolic disease.
Date Issued
2015-07-20
Date Acceptance
2015-07-06
Citation
Frontiers in Nutrition, 2015, 2
ISSN
2296-861X
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Nutrition
Volume
2
Copyright Statement
© 2015 Spreckley and Murphy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Sponsor
Biotechnology and Biological Sciences Research Cou
NC3Rs (National Centre for the Replacement, Refinement and Reduction of Animals in Research)
Grant Number
BB/E52708X/1
NC/K500379/1
Subjects
appetite
enteroendocrine
glucagon-like peptide-1
macronutrient
peptide YY
Publication Status
Published
Article Number
23