Reducing prostaglandin E2 production to raise cancer immunogenicity
File(s)
Author(s)
Zelenay, S
Reis E Sousa, C
Type
Journal Article
Abstract
Cyclooxygenases (COX), commonly upregulated in numerous cancers, generate prostaglandin E2 (PGE2), which has been implicated in key aspects of malignant growth including proliferation, invasion and angiogenesis. Recently, we showed that production of PGE2 by cancer cells dominantly enables progressive tumor growth via immune escape and that cyclooxygenase inhibitors synergize with immunotherapy to enhance tumor eradication.
Date Issued
2016-05-11
Date Acceptance
2015-11-17
Citation
Oncoimmunology, 2016, 5 (5)
ISSN
2162-4011
Publisher
Taylor & Francis
Journal / Book Title
Oncoimmunology
Volume
5
Issue
5
Copyright Statement
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
License URL
Subjects
immunotherapy
Publication Status
Published
Article Number
e1123370
Date Publish Online
2016-01-04