Susceptibility weighted imaging to detect nigral iron accumulation in Parkinson's disease
File(s)
Accepted version
Author(s)
Type
Conference Paper
Abstract
Introduction: Dopaminergic neuron loss in substantia nigra (SN) in patients with PD is associated with deposits of iron. Susceptibility weighted imaging (SWI) is a high-resolution MR-based imaging technique for quantifying iron depositions in vivo. SWI may be a robust biomarker for clinical characterization of PD.
Methods: Forty-two patients with PD were studied with SWI imaging. Average phase shift (radians) and percentage iron deposition of the SN were analysed using SPIN software. SWI data were also compared between PD patients with early (4.0±0.5 PD duration) vs. established PD (7.7±1.9), and according to low (21.2±4.5) vs. high (41.3±8.7) UPDRS-III-assessed motor symptoms severity. Data were interrogated using analysis of covariance (age), relative to healthy controls, and using post hoc univariate tests.
Results: PD patients had higher phase shift values (p<0.01) and iron deposition percentage (p<0.001) in the SN bilaterally, compared to healthy controls. Phase shift values were significantly higher in patients with established PD compared to those with early PD (p<0.05) and higher UPDRS-III motor scores (p<0.05).
Conclusions: PD patients show higher levels of deposits of iron in SN compared to healthy controls, and increased iron levels in SN are associated with prolonged disease and increased motor disability
Methods: Forty-two patients with PD were studied with SWI imaging. Average phase shift (radians) and percentage iron deposition of the SN were analysed using SPIN software. SWI data were also compared between PD patients with early (4.0±0.5 PD duration) vs. established PD (7.7±1.9), and according to low (21.2±4.5) vs. high (41.3±8.7) UPDRS-III-assessed motor symptoms severity. Data were interrogated using analysis of covariance (age), relative to healthy controls, and using post hoc univariate tests.
Results: PD patients had higher phase shift values (p<0.01) and iron deposition percentage (p<0.001) in the SN bilaterally, compared to healthy controls. Phase shift values were significantly higher in patients with established PD compared to those with early PD (p<0.05) and higher UPDRS-III motor scores (p<0.05).
Conclusions: PD patients show higher levels of deposits of iron in SN compared to healthy controls, and increased iron levels in SN are associated with prolonged disease and increased motor disability
Date Issued
2015-10-14
Date Acceptance
2015-09-10
Citation
Journal of Neurology, Neurosurgery and Psychiatry, 2015, 86 (11), pp.49-49
ISSN
0022-3050
Publisher
BMJ PUBLISHING GROUP
Start Page
49
End Page
49
Journal / Book Title
Journal of Neurology, Neurosurgery and Psychiatry
Volume
86
Issue
11
Copyright Statement
© 2015 The Author(s). This article has been accepted for publication in Journal of Neurology, Neurosurgery and Psychiatry following peer review. The definitive copyedited, typeset version
Martin-Bastida A, Politis M, Loane C, et al SUSCEPTIBILITY WEIGHTED IMAGING TO DETECT NIGRAL IRON ACCUMULATION IN PARKINSON'S DISEASE J Neurol Neurosurg Psychiatry 2015;86:e4 is available online at: https://dx.doi.org/10.1136/jnnp-2015-312379.180
Martin-Bastida A, Politis M, Loane C, et al SUSCEPTIBILITY WEIGHTED IMAGING TO DETECT NIGRAL IRON ACCUMULATION IN PARKINSON'S DISEASE J Neurol Neurosurg Psychiatry 2015;86:e4 is available online at: https://dx.doi.org/10.1136/jnnp-2015-312379.180
Sponsor
Parkinson's UK
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364994100181&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
PaMIR-RB4811 / J-1204
Source
Annual Meeting of the Association-of-British-Neurologists (ABN)
Subjects
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Psychiatry
Surgery
Neurosciences & Neurology
Neurology & Neurosurgery
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Publication Status
Published
Start Date
2015-09-10
Coverage Spatial
London, ENGLAND