Advances in mechanisms and management of chronic cough: The Ninth London International Cough Symposium 2016
File(s)
Accepted version
Author(s)
Chung, KF
Type
Journal Article
Abstract
At the Ninth London International Cough Symposium held in June 2016, advances in chronic cough were presented. Chronic cough has been labelled as a cough hypersensitivity syndrome (CHS) with neuroinflammatory mechanisms likely to be the underlying mechanisms. The concept is that there is a stage of peripheral sensitisation induced by inflammatory factors setting up the scene for a central component that can be visualised by functional magnetic resonance imaging. There has also been progress in assessing CHS patients in the clinic in terms of measuring cough, with an increasing interest in assessing different types of cough associated with respiratory diseases such as asthma, COPD, bronchiectasis and pulmonary fibrosis. There is an emerging area of new antitussives in the form of neuromodulators. These advances have been paralleled by improvements in the management of patients with chronic cough. However, more work is needed but the future looks promising.
Date Issued
2017-02-16
Date Acceptance
2017-02-12
Citation
Pulmonary Pharmacology and Therapeutics, 2017, 47, pp.2-8
ISSN
1094-5539
Publisher
Elsevier
Start Page
2
End Page
8
Journal / Book Title
Pulmonary Pharmacology and Therapeutics
Volume
47
Copyright Statement
© 2017 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
National Institute for Health Research
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/28216388
PII: S1094-5539(17)30048-2
Grant Number
NF-SI-0515-10016
Subjects
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Respiratory System
REFRACTORY CHRONIC COUGH
QUALITY-OF-LIFE
RECEPTOR POTENTIAL VANILLOID-1
IDIOPATHIC PULMONARY-FIBROSIS
RANDOMIZED CONTROLLED-TRIAL
PLACEBO-CONTROLLED TRIAL
HYPERSENSITIVITY SYNDROME
REFLEX SENSITIVITY
INCREASED EXPRESSION
NEUROPATHIC PAIN
1103 Clinical Sciences
1115 Pharmacology And Pharmaceutical Sciences
Publication Status
Published
Coverage Spatial
England