Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
Author(s)
Type
Journal Article
Abstract
A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.
Date Issued
2012-12-21
Date Acceptance
2012-11-21
Citation
Frontiers in Immunology, 2012, 3
ISSN
1664-3224
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Immunology
Volume
3
Copyright Statement
© 2012 Russ, Denton, Hatton, Croom, Olson and Turner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209501300366&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
cytotoxic T cells
memory T cells
transcription factors
epigenetics
histone modifications
TRANSCRIPTION FACTOR
EFFECTOR FUNCTION
CUTTING EDGE
CHROMATIN SIGNATURES
EARLY ESTABLISHMENT
RECALL RESPONSES
CLONAL EXPANSION
DENDRITIC CELLS
RNA-POLYMERASE
CENTRAL MEMORY
Publication Status
Published
Article Number
ARTN 371
Date Publish Online
2012-12-19