Histamine-driven responses are sustained via a bioactive metabolite
File(s)PIIS0091674919301964.pdf (1.13 MB)
Accepted version
Author(s)
Type
Journal Article
Abstract
A histamine metabolite, imidazole acetic acid (IAA), recapitulates key histamine-driven biology, including recruitment of eosinophils, induction of itch, and induction of anaphylaxis. IAA may perpetuate anaphylactic and other allergic responses after the initial release and metabolism of histamine.
Date Issued
2019-06-01
Date Acceptance
2019-01-28
Citation
Journal of Allergy and Clinical Immunology, 2019, 143 (6), pp.2287-2290.e1
ISSN
0091-6749
Publisher
Elsevier
Start Page
2287
End Page
2290.e1
Journal / Book Title
Journal of Allergy and Clinical Immunology
Volume
143
Issue
6
Copyright Statement
© 2019 American Academy of Allergy, Asthma & Immunology. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30738840
PII: S0091-6749(19)30196-4
Subjects
Anaphylaxis
histamine
imidazole acetic acid
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2019-02-08