Diagnostic accuracy of nipple aspirate fluid cytology in asymptomatic patients: a meta-analysis and systematic review of the literature
File(s)Jiwa2021_Article_DiagnosticAccuracyOfNippleAspi.pdf (626.65 KB)
Published version
Author(s)
Type
Journal Article
Abstract
PURPOSE: To calculate the diagnostic accuracy of nipple aspirate fluid (NAF) cytology. BACKGROUND: Evaluation of NAF cytology in asymptomatic patients conceptually offers a non-invasive method for either screening for breast cancer or else predicting or stratifying future cancer risk. METHODS: Studies were identified by performing electronic searches up to August 2019. A meta-analysis was conducted to attain an overall pooled sensitivity and specificity of NAF for breast cancer detection. RESULTS: A search through 938 studies yielded a total of 19 studies. Overall, 9308 patients were examined, with cytology results from 10,147 breasts [age (years), mean ± SD = 49.73 ± 4.09 years]. Diagnostic accuracy meta-analysis of NAF revealed a pooled specificity of 0.97 (95% CI 0.97-0.98), and sensitivity of 0.64 (95% CI 0.62-0.66). CONCLUSIONS: The diagnostic accuracy of nipple smear cytology is limited by poor sensitivity. If nipple fluid assessment is to be used for diagnosis, then emerging technologies for fluid biomarker analysis must supersede the current diagnostic accuracy of NAF cytology.
Date Issued
2020-11-09
Date Acceptance
2020-10-13
Citation
Annals of Surgical Oncology, 2020, 28, pp.3751-3760
ISSN
1068-9265
Publisher
Springer
Start Page
3751
End Page
3760
Journal / Book Title
Annals of Surgical Oncology
Volume
28
Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
Cancer Research UK
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33165721
PII: 10.1245/s10434-020-09313-9
Grant Number
25147
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
Surgery
BREAST-CANCER RISK
DUCTAL LAVAGE
ABNORMAL-CYTOLOGY
EXFOLIATIVE CYTOLOGY
BIOLOGIC MARKERS
GAIL MODEL
WOMEN
PREDICTION
DISCHARGE
ATYPIA
Breast Neoplasms
Cytodiagnosis
Female
Humans
Nipple Aspirate Fluid
Nipples
Sensitivity and Specificity
Nipples
Humans
Breast Neoplasms
Cytodiagnosis
Sensitivity and Specificity
Female
Nipple Aspirate Fluid
Oncology & Carcinogenesis
1112 Oncology and Carcinogenesis
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-11-09