Alcohol and Alzheimer’s Disease - does alcohol dependence contribute to beta-amyloid deposition, neuroinflammation and neurodegeneration in Alzheimer’s disease?
Author(s)
Venkataraman, A
Kalk, N
Sewell, G
Ritchie, C
Lingford-Hughes, A
Type
Journal Article
Abstract
Aim: To investigate the underlying neurobiology between alcohol use, misuse and dependence and cognitive impairment, particularly Alzheimer’s disease. Methods: Review of the literature using searches of Medline, Pubmed, EMBASE, PsycInfo, and meeting abstracts and presentations. Results: The role of alcohol as a risk factor and contributor for cognitive decline associated with Alzheimer’s disease (AD) has received little attention. This is despite the high prevalence of alcohol use, the potential reversibility of a degree of cognitive impairment and the global burden of AD. Until now the focus has largely been on the toxic effects of alcohol, neuronal loss and the role of thiamine. Conclusions: We propose alcohol adds to the cognitive burden seen in dementia through additional mechanisms to neurodegenerative processes or may contribute at various mechanistic points in the genesis and sustenance of AD pathology via neuroinflammation. We describe the common underlying neurobiology in alcohol and AD, and examine ways alcohol likely contributes to neuroinflammation directly via stimulation of Toll-like receptors and indirectly from small bowel changes, hepatic changes, withdrawal and traumatic brain injury to the pathogenesis of AD.
Date Issued
2016-12-21
Date Acceptance
2016-11-07
ISSN
0735-0414
Publisher
Oxford University Press (OUP)
Start Page
151
End Page
158
Journal / Book Title
Alcohol and Alcoholism
Volume
52
Issue
2
Copyright Statement
© The Author 2016. Medical Council on Alcohol and Oxford University Press. All rights reserved. This is a pre-copy-editing, author-produced version of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version is available online at: https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agw092
Sponsor
Alzheimer's Research UK (ARUK)
Alzheimer's Research UK (ARUK)
Grant Number
ARUK-PCRF2016A-2
ARUK-PCRF20164A-2
Subjects
Science & Technology
Life Sciences & Biomedicine
Substance Abuse
TOLL-LIKE RECEPTORS
INNATE IMMUNE ACTIVATION
BINGE ETHANOL EXPOSURE
BRAIN-DAMAGE
MICROGLIAL ACTIVATION
COGNITIVE DEFICITS
MOUSE MODEL
BENZODIAZEPINE RECEPTORS
CONSUMPTION
INFLAMMATION
1117 Public Health And Health Services
1701 Psychology
1109 Neurosciences
Publication Status
Published