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Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression.
File(s)
Author(s)
O'Shea, PJ
Bassett, JH
Cheng, SY
Williams, GR
Type
Journal Article
Abstract
Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) alpha1 or beta gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.
Date Issued
2006-01-31
URI
DOI
Start Page
e011
Journal / Book Title
Nucl Recept Signal
Volume
4
Copyright Statement
Copyright © 2006, O'Shea et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Description
24.02.14 KB. Ok to add published paper to spiral, OA article.
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/16862217
Coverage Spatial
United States