Task-related changes in resting state connectivity are affected by temporal interference (TI) stimulation
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Background
Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acutely modulate activity or FC traces of preceding cognitive tasks.
Objectives
We evaluated whether non-invasive temporal interference (TI) stimulation of the hippocampus can modulate hippocampal resting-state FC traces induced by a preceding hippocampally-dependent task.
Methods
We collected resting-state functional magnetic resonance imaging (rsfMRI) in twenty healthy participants before and after the performance of an associative memory task. Theta-band TI stimulation of the medial and anterior hippocampus, and sham stimulation were delivered during post-task resting state. We used permutation tests to assess differences in pairwise mutual information functional connectivity (miFC) between pre-task rsfMRI vs post-task sham. In edges with significantly different pre-vs post-task miFC, permutation tests assessed the effect of TI on post-task miFC.
Results
MiFC was significantly lower in several functional networks during post-task sham compared to pre-task baseline, including the hippocampal-connected and task-related Anterior Temporal (AT) and Posterior Medial (PM) networks. TI stimulation of the hippocampus during post-task resting state increased the miFC in the hippocampal AT and PM networks as well as other functional networks.
Conclusions
Non-invasive TI stimulation of the hippocampus during the resting state acutely modulated FC traces related to preceding hippocampal-dependent memory tasks.
Resting-state metrics, such as brain network activity and functional connectivity (FC), are influenced by preceding cognitive tasks, such as memory formation. Brain stimulation can modulate brain network activity and FC during the resting state. However, it is unknown whether it can acutely modulate activity or FC traces of preceding cognitive tasks.
Objectives
We evaluated whether non-invasive temporal interference (TI) stimulation of the hippocampus can modulate hippocampal resting-state FC traces induced by a preceding hippocampally-dependent task.
Methods
We collected resting-state functional magnetic resonance imaging (rsfMRI) in twenty healthy participants before and after the performance of an associative memory task. Theta-band TI stimulation of the medial and anterior hippocampus, and sham stimulation were delivered during post-task resting state. We used permutation tests to assess differences in pairwise mutual information functional connectivity (miFC) between pre-task rsfMRI vs post-task sham. In edges with significantly different pre-vs post-task miFC, permutation tests assessed the effect of TI on post-task miFC.
Results
MiFC was significantly lower in several functional networks during post-task sham compared to pre-task baseline, including the hippocampal-connected and task-related Anterior Temporal (AT) and Posterior Medial (PM) networks. TI stimulation of the hippocampus during post-task resting state increased the miFC in the hippocampal AT and PM networks as well as other functional networks.
Conclusions
Non-invasive TI stimulation of the hippocampus during the resting state acutely modulated FC traces related to preceding hippocampal-dependent memory tasks.
Date Issued
2025-05-01
Date Acceptance
2025-04-09
Citation
Brain Stimulation, 2025, 18 (3), pp.937-947
ISSN
1935-861X
Publisher
Elsevier BV
Start Page
937
End Page
947
Journal / Book Title
Brain Stimulation
Volume
18
Issue
3
Copyright Statement
© 2025 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Identifier
10.1016/j.brs.2025.04.010
Publication Status
Published
Date Publish Online
2025-04-23