Mapping trends in insecticide resistance phenotypes in African malaria vectors
File(s)
Author(s)
Type
Journal Article
Abstract
Mitigating the threat of insecticide resistance in African malaria vector populations requires comprehensive information about where resistance occurs, to what degree, and how this has changed over time. Estimating these trends is complicated by the sparse, heterogeneous distribution of observations of resistance phenotypes in field populations. We use 6,423 observations of the prevalence of resistance to the most important vector control insecticides to inform a Bayesian geostatistical ensemble modelling approach, generating fine-scale predictive maps of resistance phenotypes in mosquitoes from the Anopheles gambiae complex across Africa. Our models are informed by a suite of 111 predictor variables describing potential drivers of selection for resistance. Our maps show alarming increases in the prevalence of resistance to pyrethroids and DDT across sub-Saharan Africa from 2005 to 2017, with mean mortality following insecticide exposure declining from almost 100% to less than 30% in some areas, as well as substantial spatial variation in resistance trends.
Date Issued
2020-06-01
Date Acceptance
2020-05-11
Citation
PLoS Biology, 2020, 18 (6), pp.1-23
ISSN
1544-9173
Publisher
Public Library of Science (PLoS)
Start Page
1
End Page
23
Journal / Book Title
PLoS Biology
Volume
18
Issue
6
Copyright Statement
© 2020 Hancock et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License URL
Sponsor
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000545761300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
MR/R015600/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biology
Life Sciences & Biomedicine - Other Topics
ANOPHELES-GAMBIAE
GENE-FLOW
POPULATION-STRUCTURE
COMPLEX
ARABIENSIS
MOSQUITOS
DYNAMICS
BARRIER
Publication Status
Published
Article Number
ARTN e3000633
Date Publish Online
2020-06-25