Strategic design of extracellular vesicle drug delivery systems
File(s)
Accepted version
Author(s)
Armstrong, JP
Stevens, MM
Type
Journal Article
Abstract
Extracellular vesicles (EVs), sub-micron vectors used in intercellular communication, have demonstrated great promise as natural drug delivery systems. Recent reports have detailed impressive in vivo results from the administration of EVs pre-loaded with therapeutic cargo, including small molecules, nanoparticles, proteins and oligonucleotides. These results have sparked intensive research interest across a huge range of disease models. There are, however, enduring limitations that have restricted widespread clinical and pharmaceutical adoption. In this perspective, we discuss these practical and biological concerns, critically compare the relative merit of EVs and synthetic drug delivery systems, and highlight the need for a more comprehensive understanding of in vivo transport and delivery. Within this framework, we seek to establish key areas in which EVs can gain a competitive advantage in order to provide the tangible added value required for widespread translation.
Date Issued
2018-06-28
Date Acceptance
2018-06-22
Citation
Advanced Drug Delivery Reviews, 2018, 130, pp.12-16
ISSN
0169-409X
Publisher
Elsevier
Start Page
12
End Page
16
Journal / Book Title
Advanced Drug Delivery Reviews
Volume
130
Copyright Statement
© 2018 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
Commission of the European Communities
Wellcome Trust
GlaxoSmithKline Services Unlimited
Arthritis Research UK
Arthritis Research UK
Grant Number
MR/K026682/1
MR/L012677/1
ERC-2013-CoG-616417
098411/Z/12/Z
Mark Buswell
21138
21138
Subjects
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Drug delivery
Extracellular vesicles
Exosomes
Microvesicles
Liposomes
LIPOSOME-ENCAPSULATED DOXORUBICIN
BLOOD-BRAIN-BARRIER
IN-VIVO
CANCER-CELLS
INTRAVENOUS-INJECTION
INFLAMMATORY DISEASES
TUMOR-GROWTH
EXOSOMES
THERAPY
MICE
Drug delivery
Exosomes
Extracellular vesicles
Liposomes
Microvesicles
1115 Pharmacology and Pharmaceutical Sciences
Pharmacology & Pharmacy
Publication Status
Published
Date Publish Online
2018-06-28