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Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless 'Frank-Starling Gain' index
File(s)
Author(s)
Bollensdorff, C
Lookin, O
Kohl, P
Type
Journal Article
Abstract
This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
Date Issued
2011-04-15
Date Acceptance
2011-03-28
Citation
Pflügers Archiv European Journal of Physiology, 2011, 462 (1), pp.39-48
URI
URL
DOI
ISSN
0031-6768
Publisher
Springer
Start Page
39
End Page
48
Journal / Book Title
Pflügers Archiv European Journal of Physiology
Volume
462
Issue
1
Copyright Statement
© The Author(s) 2011. This article is published with open access at Springerlink.com. This article is distributed under the terms of the
Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any
medium, provided the original author(s) and source are credited.
License URL
Sponsor
British Heart Foundation
Identifier
https://link.springer.com/article/10.1007%2Fs00424-011-0964-z
Grant Number
PG/09/031/27221
Subjects
Science & Technology
Life Sciences & Biomedicine
Physiology
Heart
Stretch
Positive inotropic response
Cardiac mechanics
Mechanosensitivity
LENGTH-DEPENDENT ACTIVATION
PRESSURE-VOLUME RELATIONSHIP
RAT CARDIAC TRABECULAE
RABBIT SKELETAL-MUSCLE
SINGLE-CELL MECHANICS
SARCOMERE-LENGTH
DILATED CARDIOMYOPATHY
THEORETICAL-MODELS
CA2+ SENSITIVITY
ACTIVE TENSION
Animals
Models, Cardiovascular
Myocardial Contraction
Myocytes, Cardiac
Stress, Mechanical
Myocytes, Cardiac
Animals
Myocardial Contraction
Stress, Mechanical
Models, Cardiovascular
Physiology
0606 Physiology
1106 Human Movement and Sports Sciences
1116 Medical Physiology
Notes
Bollensdorff, Christian Lookin, Oleg Kohl, Peter This paper briefly recapitulates the Frank-Starling law of the heart, reviews approaches to establishing diastolic and systolic force-length behaviour in intact isolated cardiomyocytes, and introduces a dimensionless index called 'Frank-Starling Gain', calculated as the ratio of slopes of end-systolic and end-diastolic force-length relations. The benefits and limitations of this index are illustrated on the example of regional differences in Guinea pig intact ventricular cardiomyocyte mechanics. Potential applicability of the Frank-Starling Gain for the comparison of cell contractility changes upon stretch will be discussed in the context of intra- and inter-individual variability of cardiomyocyte properties.
Publication Status
Published
Date Publish Online
2011-04-15