Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma
File(s)
Published version
Author(s)
Capece, Daria
Franzoso, Guido
Type
Journal Article
Abstract
Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC
Date Issued
2022-01-20
Date Acceptance
2021-12-22
Citation
Molecular and Cellular Oncology, 2022, 9 (1)
ISSN
2372-3556
Publisher
Taylor and Francis
Journal / Book Title
Molecular and Cellular Oncology
Volume
9
Issue
1
Copyright Statement
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000750147000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
CONSENSUS MOLECULAR SUBTYPES
FATTY-ACID OXIDATION
CANCER
OBESITY
Publication Status
Published
Article Number
2024051
Date Publish Online
2022-01-27