Stem cell death and survival in heart regeneration and repair
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Cardiovascular diseases are major causes of mortality and morbidity. Cardiomyocyte apoptosis disrupts cardiac function and leads to cardiac decompensation and terminal heart failure. Delineating the regulatory signaling pathways that orchestrate cell survival in the heart has significant therapeutic implications. Cardiac tissue has limited capacity to regenerate and repair. Stem cell therapy is a successful approach for repairing and regenerating ischemic cardiac tissue; however, transplanted cells display very high death percentage, a problem that affects success of tissue regeneration. Stem cells display multipotency or pluripotency and undergo self-renewal, however these events are negatively influenced by upregulation of cell death machinery that induces the significant decrease in survival and differentiation signals upon cardiovascular injury. While efforts to identify cell types and molecular pathways that promote cardiac tissue regeneration have been productive, studies that focus on blocking the extensive cell death after transplantation are limited. The control of cell death includes multiple networks rather than one crucial pathway, which underlies the challenge of identifying the interaction between various cellular and biochemical components. This review is aimed at exploiting the molecular mechanisms by which stem cells resist death signals to develop into mature and healthy cardiac cells. Specifically, we focus on a number of factors that control death and survival of stem cells upon transplantation and ultimately affect cardiac regeneration. We also discuss potential survival enhancing strategies and how they could be meaningful in the design of targeted therapies that improve cardiac function.
Date Issued
2015-12-19
Date Acceptance
2015-12-19
Citation
Apoptosis, 2015, 21 (3), pp.252-268
ISSN
1573-675X
Publisher
Springer Verlag
Start Page
252
End Page
268
Journal / Book Title
Apoptosis
Volume
21
Issue
3
Copyright Statement
© Springer Verlag 2015. The final publication is available at Springer via http://dx.doi.org/10.1007/s10495-015-1203-4
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Cell death
Stem cells
Apoptosis
Therapy
Heart
Regeneration
DEPRIVATION-INDUCED APOPTOSIS
RECEPTOR-STIMULATED APOPTOSIS
SIGNAL-TRANSDUCTION PATHWAYS
ACUTE MYOCARDIAL-INFARCTION
PRESERVES CARDIAC-FUNCTION
PROTEIN-KINASE-B
BONE-MARROW
OXIDATIVE STRESS
IN-VIVO
ISCHEMIC-HEART
0601 Biochemistry And Cell Biology
1116 Medical Physiology
Publication Status
Published