Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli
File(s)
Published version
Author(s)
Brown, DR
Barton, G
Pan, Z
Buck, M
Wigneshweraraj
Type
Journal Article
Abstract
Nitrogen is an essential element for all life, and this is
no different for the bacterial cell. Numerous cellular
macromolecules contain nitrogen, including proteins,
nucleic acids and cell wall components. In Escherichia
coli and related bacteria, the nitrogen stress (Ntr) response
allows cells to rapidly sense and adapt to nitrogen
limitation by scavenging for alternative nitrogen
sources through the transcriptional activation of
transport systems and catabolic and biosynthetic operons
by the global transcriptional regulator NtrC. Nitrogen-starved
bacterial cells also synthesize the
(p)ppGpp effector molecules of a second global bacterial
stress response - the stringent response. Recently,
we showed that the transcription of relA, the gene
which encodes the major (p)ppGpp synthetase in E.
coli, is activated by NtrC during nitrogen starvation.
Our results revealed that in E. coli and related bacteria,
NtrC functions in combinatorial stress and serves to
couple two major stress responses, the Ntr response
and stringent response.
no different for the bacterial cell. Numerous cellular
macromolecules contain nitrogen, including proteins,
nucleic acids and cell wall components. In Escherichia
coli and related bacteria, the nitrogen stress (Ntr) response
allows cells to rapidly sense and adapt to nitrogen
limitation by scavenging for alternative nitrogen
sources through the transcriptional activation of
transport systems and catabolic and biosynthetic operons
by the global transcriptional regulator NtrC. Nitrogen-starved
bacterial cells also synthesize the
(p)ppGpp effector molecules of a second global bacterial
stress response - the stringent response. Recently,
we showed that the transcription of relA, the gene
which encodes the major (p)ppGpp synthetase in E.
coli, is activated by NtrC during nitrogen starvation.
Our results revealed that in E. coli and related bacteria,
NtrC functions in combinatorial stress and serves to
couple two major stress responses, the Ntr response
and stringent response.
Date Issued
2014-09-01
Date Acceptance
2014-08-21
Citation
Microbial Cell, 2014, 1 (9), pp.315-317
ISSN
2311-2638
Publisher
Shared Science Publishers
Start Page
315
End Page
317
Journal / Book Title
Microbial Cell
Volume
1
Issue
9
Copyright Statement
© 2014 Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli by Daniel R. Brown et al. is licensed under a Creative Commons Attribution 4.0 International License.
License URL
Publication Status
Published