The Gut microbiome in polycystic ovary syndrome and its association with metabolic traits
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
CONTEXT: Despite gut microbiome being widely studied in metabolic diseases, its role in polycystic ovary syndrome (PCOS) has been scarcely investigated. OBJECTIVE: Compare the gut microbiome in late fertile age women with and without PCOS and investigate whether changes in the gut microbiome correlate with PCOS-related metabolic parameters. DESIGN: Prospective, case-control study using the Northern Finland Birth Cohort 1966. SETTING: General community. PARTICIPANTS: 102 PCOS women and 201 age- and body mass index (BMI)-matched non-PCOS control women. Clinical and biochemical characteristics of the participants were assessed at ages 31 and 46 and analyzed in the context of gut microbiome data at the age of 46. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Bacterial diversity, relative abundance, and correlations with PCOS-related metabolic measures. RESULTS: Bacterial diversity indices did not differ significantly between PCOS and controls (Shannon diversity p = 0.979, unweighted UniFrac p = 0.175). Four genera whose balance helps to differentiate between PCOS and non-PCOS were identified. In the whole cohort, the abundance of two genera from Clostridiales, Ruminococcaceae UCG-002 and Clostridiales Family XIII AD3011 group, were correlated with several PCOS-related markers. Prediabetic PCOS women had significantly lower alpha diversity (Shannon diversity p = 0.018) and markedly increased abundance of genus Dorea (FDR = 0.03) compared to women with normal glucose tolerance. CONCLUSION: PCOS and non-PCOS women at late fertile age with similar BMI do not significantly differ in their gut microbial profiles. However, there are significant microbial changes in PCOS individuals depending on their metabolic health.
Date Issued
2021-03
Date Acceptance
2020-11-10
Citation
Journal of Clinical Endocrinology and Metabolism, 2021, 106 (3), pp.858-871
ISSN
0021-972X
Publisher
Oxford University Press (OUP)
Start Page
858
End Page
871
Journal / Book Title
Journal of Clinical Endocrinology and Metabolism
Volume
106
Issue
3
Copyright Statement
© 2020 Oxford University Press. This is a pre-copy-editing, author-produced version of an article accepted for publication in Journal of Clinical Endocrinology and Metabolism following peer review. The definitive publisher-authenticated version Kreete Lüll, Riikka K Arffman, Alberto Sola-Leyva, Nerea M Molina, Oliver Aasmets, Karl-Heinz Herzig, Julio Plaza-Díaz, Stephen Franks, Laure Morin-Papunen, Juha S Tapanainen, Andres Salumets, Signe Altmäe, Terhi T Piltonen, Elin Org, The Gut Microbiome in Polycystic Ovary Syndrome and Its Association with Metabolic Traits, The Journal of Clinical Endocrinology & Metabolism, dgaa848, is available online at https://doi.org/10.1210/clinem/dgaa848
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33205157
PII: 5986713
Subjects
PCOS
gut microbiome
metabolic traits
type 2 diabetes
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-11-17