We introduce a rigorous framework for the quantification of coherence and identify intuitive and easily computable measures of coherence. We achieve this by adopting the viewpoint of coherence as a physical resource. By determining defining conditions for measures of coherence we identify classes of functionals that satisfy these conditions and other, at first glance natural quantities, that do not qualify as coherence measures. We conclude with an outline of the questions that remain to be answered to complete the theory of coherence as a resource.