Influence of atherosclerotic plaque on stress distribution of layer-specific coronary arteries in the presence of residual stress
File(s)
Author(s)
Bagheri Pormehr, Negin
Type
Thesis or dissertation
Abstract
Atherosclerosis is defined as the thickening of an artery due to the
accumulation of fatty acids, cholesterol, and cellular debris within the blood vessel
lining. This research aims to understand the influence of atherosclerotic plaque on
residual stress within t
he arterial layers. Three layers of human coronary artery were
studied under the influence of blood loading. Residual stress due to the opening angle
and longitudinal stretch was included in the numerical model of the artery. A new
method is used for
model
ing
the effect of the opening angle on the distribution of
stress. The finite element method was used for the numerical
modeling
of the artery in
both healthy and atherosclerotic conditions. Under the blood loading condition, it was
found that the presence
of plaque produces higher stress in the arterial wall. This
study allows us to investigate how the presence of the plaque
affects
residual stress
and the overall stress distribution in the artery wall.
accumulation of fatty acids, cholesterol, and cellular debris within the blood vessel
lining. This research aims to understand the influence of atherosclerotic plaque on
residual stress within t
he arterial layers. Three layers of human coronary artery were
studied under the influence of blood loading. Residual stress due to the opening angle
and longitudinal stretch was included in the numerical model of the artery. A new
method is used for
model
ing
the effect of the opening angle on the distribution of
stress. The finite element method was used for the numerical
modeling
of the artery in
both healthy and atherosclerotic conditions. Under the blood loading condition, it was
found that the presence
of plaque produces higher stress in the arterial wall. This
study allows us to investigate how the presence of the plaque
affects
residual stress
and the overall stress distribution in the artery wall.
Version
Open Access
Date Issued
2013-03
Date Awarded
2013-07
Advisor
Krams, Rob
Creator
Bagheri Pormehr, Negin
Publisher Department
Bioengineering
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Master of Philosophy (MPhil)