Genome-wide analysis identifies 12 loci influencing human reproductive behavior
File(s)
Accepted version
Accepted version
Author(s)
Type
Journal Article
Abstract
The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Date Issued
2016-10-31
Date Acceptance
2016-09-22
Citation
Nature Genetics, 2016, 48 (12), pp.1462-1472
ISSN
1061-4036
Publisher
Nature Publishing Group
Start Page
1462
End Page
1472
Journal / Book Title
Nature Genetics
Volume
48
Issue
12
Copyright Statement
Copyright © 2016, Rights Managed by Nature Publishing Group
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
POLYCYSTIC-OVARY-SYNDROME
GENE PRIORITIZATION
QUALITY-CONTROL
HUMAN-DISEASES
G1 PHASE
ASSOCIATION
FERTILITY
MOUSE
PROTEIN
AGE
Publication Status
Published