Disease prevention not decolonization – a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms
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Supporting information
Published version
Author(s)
Type
Journal Article
Abstract
Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia and length of stay in 20 patients colonized/ infected with MDRO receiving FMT (compared to pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.
Date Issued
2021-04-15
Date Acceptance
2020-06-08
Citation
Clinical Infectious Diseases, 2021, 72 (8), pp.1444-1447
ISSN
1058-4838
Publisher
Oxford University Press (OUP)
Start Page
1444
End Page
1447
Journal / Book Title
Clinical Infectious Diseases
Volume
72
Issue
8
Copyright Statement
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Supplementary data
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Supplementary data
Sponsor
Medical Research Council
Medical Research Council (MRC)
Imperial College Healthcare NHS Trust- BRC Funding
NIHR
Wellcome Trust Institutional Strategic Support Fund (co-funded by Wellcome Trust and Imperial College London)
Imperial College Healthcare NHS Trust: Research Capability Funding (RCF)
Identifier
https://academic.oup.com/cid/article/doi/10.1093/cid/ciaa948/5873448
Grant Number
MR/R00875/1
MR/R000875/1
RDA02
RDF04
Subjects
allogeneic hematopoietic cell transplantation
antimicrobial resistance
fecal microbiota transplant
gut microbiome
multi-drug resistant bacteria
Microbiology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2020-07-18