A restrictive spirometry pattern is associated with high morbidity and mortality. Whether practicing regular physical activity protects against this pattern has never been studied. We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and physical activity were assessed between 2000–2002 in the ECRHS (n=2,757, 39-67 years) and SAPALDIA (n=2,610, 36–82 years) population-based European cohorts, and again approximately 10-years later (2010–2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active ≥2-3 times/wk for ≥1 h) with restrictive spirometry pattern at follow-up (defined as a post-bronchodilator FEV1/FVC ≥Lower Limit of Normal and FVC<80% predicted) using modified Poisson regression, adjusting for relevant confounders. After 10 years of follow-up, 3.3% of participants had developed restrictive spirometry pattern. Being physically active was associated with a lower risk of developing this phenotype (RR=0.76, 95% CI=0.59-0.98). This association was stronger among those overweight and obese, compared to those with normal weight (Pinteraction=0.06). In two large European studies, adults practicing regular physical activity were at lower risk of developing restrictive spirometry pattern after 10 years.