Vaccine uptake and SARS-CoV-2 antibody prevalence among 207,337 adults during May 2021 in England: REACT-2 study
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Supporting information
Working paper
Author(s)
Type
Working Paper
Abstract
Background The programme to vaccinate adults in England has been rapidly implemented
since it began in December 2020. The community prevalence of SARS-CoV-2 anti-spike
protein antibodies provides an estimate of total cumulative response to natural infection and
vaccination. We describe the distribution of SARS-CoV-2 IgG antibodies in adults in
England in May 2021 at a time when approximately 7 in 10 adults had received at least one
dose of vaccine.
Methods Sixth round of REACT-2 (REal-time Assessment of Community Transmission-2),
a cross-sectional random community survey of adults in England, from 12 to 25 May 2021;
207,337 participants completed questionnaires and self-administered a lateral flow
immunoassay test producing a positive or negative result.
Results Vaccine coverage with one or more doses, weighted to the adult population in
England, was 72.9% (95% confidence interval 72.7-73.0), varying by age from 25.1% (24.5-
25.6) of those aged 18 to 24 years, to 99.2% (99.1-99.3) of those 75 years and older. In
adjusted models, odds of vaccination were lower in men (odds ratio [OR] 0.89 [0.85-0.94])
than women, and in people of Black (0.41 [0.34-0.49]) compared to white ethnicity. There
was higher vaccine coverage in the least deprived and highest income households. People
who reported a history of COVID-19 were less likely to be vaccinated (OR 0.61 [0.55-0.67]).
There was high coverage among health workers (OR 9.84 [8.79-11.02] and care workers (OR
4.17 [3.20-5.43]) compared to non-key workers, but lower in hospitality and retail workers
(OR 0.73 [0.64-0.82] and 0.77 [0.70-0.85] respectively) after adjusting for age and key
covariates.
since it began in December 2020. The community prevalence of SARS-CoV-2 anti-spike
protein antibodies provides an estimate of total cumulative response to natural infection and
vaccination. We describe the distribution of SARS-CoV-2 IgG antibodies in adults in
England in May 2021 at a time when approximately 7 in 10 adults had received at least one
dose of vaccine.
Methods Sixth round of REACT-2 (REal-time Assessment of Community Transmission-2),
a cross-sectional random community survey of adults in England, from 12 to 25 May 2021;
207,337 participants completed questionnaires and self-administered a lateral flow
immunoassay test producing a positive or negative result.
Results Vaccine coverage with one or more doses, weighted to the adult population in
England, was 72.9% (95% confidence interval 72.7-73.0), varying by age from 25.1% (24.5-
25.6) of those aged 18 to 24 years, to 99.2% (99.1-99.3) of those 75 years and older. In
adjusted models, odds of vaccination were lower in men (odds ratio [OR] 0.89 [0.85-0.94])
than women, and in people of Black (0.41 [0.34-0.49]) compared to white ethnicity. There
was higher vaccine coverage in the least deprived and highest income households. People
who reported a history of COVID-19 were less likely to be vaccinated (OR 0.61 [0.55-0.67]).
There was high coverage among health workers (OR 9.84 [8.79-11.02] and care workers (OR
4.17 [3.20-5.43]) compared to non-key workers, but lower in hospitality and retail workers
(OR 0.73 [0.64-0.82] and 0.77 [0.70-0.85] respectively) after adjusting for age and key
covariates.
Date Issued
2021-07-15
Citation
2021
Copyright Statement
© 2021 The Author(s)
Subjects
SARS-CoV-2 coronavirus research
Publication Status
Published