Current estimates of T cell kinetics in humans
File(s)
Supporting information
Published version
Author(s)
Macallan, Derek
Busch, Robert
Asquith, Becca
Type
Journal Article
Abstract
Stable isotope labelling is a generally applicable method of quantifying cell dynamics. Its advent has opened up the way for the quantitative study of T cells in humans. However, the literature is confusing as estimates vary by orders of magnitude between studies. In this short review we aim to explain the reasons for the discrepancies in estimates, clarify which estimates have been superseded and why and highlight the current best estimates. We focus on stable isotope labelling of T cell subsets in healthy humans.
Date Issued
2019-12
Date Acceptance
2019-10-24
Citation
Current Opinion in Systems Biology, 2019, 18, pp.77-86
ISSN
2452-3100
Publisher
Elsevier
Start Page
77
End Page
86
Journal / Book Title
Current Opinion in Systems Biology
Volume
18
Copyright Statement
© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ).
Sponsor
Commission of the European Communities
Wellcome Trust
Grant Number
317040
103865/Z/14/Z
Publication Status
Published
Date Publish Online
2019-11-06