A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants
File(s)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
The aim of this study was to propose and validate a new unified method for testing dissolution rates of bioactive glasses and their variants, and the formation of calcium phosphate layer formation on their surface, which is an indicator of bioactivity. At present, comparison in the literature is difficult as many groups use different testing protocols. An ISO standard covers the use of simulated body fluid on standard shape materials but it does not take into account that bioactive glasses can have very different specific surface areas, as for glass powders. Validation of the proposed modified test was through round robin testing and comparison to the ISO standard where appropriate. The proposed test uses fixed mass per solution volume ratio and agitated solution. The round robin study showed differences in hydroxyapatite nucleation on glasses of different composition and between glasses of the same composition but different particle size. The results were reproducible between research facilities. Researchers should use this method when testing new glasses, or their variants, to enable comparison between the literature in the future.
Date Issued
2015-02-11
Date Acceptance
2014-11-01
Citation
Journal of Materials Science: Materials in Medicine, 2015, 26 (2), pp.1-10
ISSN
0957-4530
Publisher
Springer
Start Page
1
End Page
10
Journal / Book Title
Journal of Materials Science: Materials in Medicine
Volume
26
Issue
2
Copyright Statement
The final publication is available at Springer via https://dx.doi.org/10.1007/s10856-015-5403-9
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://link.springer.com/article/10.1007/s10856-015-5403-9
Grant Number
EP/I020861/1
Subjects
Science & Technology
Technology
Engineering, Biomedical
Materials Science, Biomaterials
Engineering
Materials Science
SCAFFOLDS
SYSTEM
GROWTH
HYDROXYAPATITE
DISSOLUTION
IMPLANTS
BEHAVIOR
POWDERS
45S5
FTIR
Publication Status
Published
Article Number
115
Date Publish Online
2015-02-11