Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
Author(s)
Type
Journal Article
Abstract
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be
partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association
studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects.
We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and
SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA.
Our findings advance the understanding of the pharmacogenetic architecture of statin response.
partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association
studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects.
We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and
SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA.
Our findings advance the understanding of the pharmacogenetic architecture of statin response.
Date Issued
2014-10-28
Date Acceptance
2014-08-22
Citation
Nature Communications, 2014, 5
ISSN
2041-1723
Publisher
Nature Publishing Group
Journal / Book Title
Nature Communications
Volume
5
Copyright Statement
© 2014 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 4.0
International License. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise
in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
International License. The images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise
in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
License URL
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
PLASMA LIPOPROTEIN(A) LEVELS
HUMAN PREFRONTAL CORTEX
GENE-EXPRESSION
WHOLE-GENOME
INDUCED MYOPATHY
DISEASE
LOCI
VARIANTS
THERAPY
BLOOD
Publication Status
Published
Article Number
5068