Impact of G protein-coupled receptor heteromers in endocrine systems
File(s)
Accepted version
Author(s)
Jonas, KC
Hanyaloglu, AC
Type
Journal Article
Abstract
The fine-tuning of endocrine homeostasis is regulated by dynamic receptor mediated processes. The
superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine
axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment
of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key
mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization
and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring
current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine
heath and disease.
superfamily of G protein-coupled receptors (GPCRs) have diverse roles in the modulation of all endocrine
axes, thus understanding the mechanisms underpinning their functionality is paramount for treatment
of endocrinopathies. Evidence over the last 20 years has highlighted homo and heteromerization as a key
mode of mediating GPCR functional diversity. This review will discuss the concept of GPCR heteromerization
and its relevance to endocrine function, detailing in vitro and in vivo evidence, and exploring
current and potential pharmacological strategies for specific targeting of GPCR heteromers in endocrine
heath and disease.
Date Issued
2017-01-20
Date Acceptance
2017-01-19
Citation
Molecular and Cellular Endocrinology, 2017, 449, pp.21-27
ISSN
0303-7207
Publisher
Elsevier
Start Page
21
End Page
27
Journal / Book Title
Molecular and Cellular Endocrinology
Volume
449
Copyright Statement
© 2017 Published by Elsevier Ireland Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000402944900004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
BB/I008004/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Endocrinology & Metabolism
GPCR
Dimer
Oligomer
Signaling
Heteromer
RESONANCE ENERGY-TRANSFER
ANGIOTENSIN-II RESPONSIVENESS
SINGLE-MOLECULE ANALYSIS
HUMAN LUTROPIN RECEPTOR
TIME-RESOLVED FRET
LUTEINIZING-HORMONE
TASTE RECEPTORS
HUMAN GRANULOSA
TRANSFER BRET
IN-VIVO
06 Biological Sciences
11 Medical And Health Sciences
07 Agricultural And Veterinary Sciences
Publication Status
Published