In an attempt to realise next-generation lightweight parts and to fully utilize the inherent design
freedom of AM, we propose a topology optimization based design procedure that includes the anisotropic considerations for continuous fibre printing of variable stiffness composites. In this paper, we aim to improve the normalized compliance of a beam in a three-point bending scenario, using a skeletal reinforcement for a topology in which the change in fibre orientation is derived from the medial axis information. FDM with a dual-nozzle system printing nylon and carbon fibre filaments were utilized for fabrication. The toolpath i.e. reinforcement strategy available from the commercial software Eiger® was chosen to imitate the proposed strategy. The numerical investigation is complemented with experimental tests and a general benchmarking is conducted using standard pedants. The results have shown improved specific flexural stiffness for samples with skeletal reinforcement. The skeletal information is therefore considered as important tool for the retrieval of fibre angles which align with the principle stresses and therefore allow for a more efficient fibre placement in AM parts for future lightweight end-use parts.