The risk of Kawasaki disease after Pneumococcal conjugate & Meningococcal B vaccine in England: a self-controlled case-series analysis
File(s)
Accepted version
Author(s)
Turner, Paul
Type
Journal Article
Abstract
Kawasaki disease (KD) is an uncommon condition occasionally reported after childhood vaccination. Admissions with a KD-compatible diagnosis identified from a national database in England were linked to immunisation records to investigate the risk after pneumococcal conjugate (PCV) or meningococcal B (MenB) vaccines. Both are given at 2/4/12 months of age but were introduced sequentially, allowing their effects to be separately assessed. A total of 553 linked admissions in 512 individuals were validated as KD. The relative incidence (RI) within 28 days of PCV doses 1 or 2 measured by the self-controlled case-series method was 0.62 (95% confidence interval (CI) 0.38–1.00) with a significantly decreased risk after dose 3 (RI 0.30 (95% CI 0.11–0.77)). For MenB vaccine, the RI after doses 1 or 2 was 1.03 (95% CI 0.51–2.05) and 0.64 (95% CI 0.08–5.26) after dose 3. This study shows no evidence of an increased risk of KD after either vaccine.
Date Issued
2020-07-06
Date Acceptance
2020-05-28
Citation
Vaccine, 2020, 38 (32), pp.4935-4939
ISSN
0264-410X
Publisher
Elsevier
Start Page
4935
End Page
4939
Journal / Book Title
Vaccine
Volume
38
Issue
32
Copyright Statement
© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Department of Health
Identifier
https://www.sciencedirect.com/science/article/pii/S0264410X20307568?via%3Dihub
Grant Number
039/0031
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
Kawasaki disease
Pneumococcal conjugate vaccine
Meningococcal B vaccine
Self-controlled case-series
IMMUNIZATION
Kawasaki disease
Meningococcal B vaccine
Pneumococcal conjugate vaccine
Self-controlled case-series
Virology
06 Biological Sciences
07 Agricultural and Veterinary Sciences
11 Medical and Health Sciences
Publication Status
Published
Date Publish Online
2020-06-11