The mechanism of action of clozapine
File(s)
Published version
Author(s)
Morrison, Paul D
Jauhar, Sameer
Young, Allan H
Type
Journal Article
Abstract
Previous hypotheses for the superiority of clozapine over other antipsychotics have failed to stand the test of time. Here we describe how the unique pharmacology of clozapine in the peripheral nervous system held clues for solving the puzzle of clozapine in the central nervous system. Clozapine appears to have been the prototype for a new class of antipsychotics, now entering clinical psychiatry, which activates muscarinic acetylcholine receptors.
Date Issued
2025-04-01
Date Acceptance
2025-02-01
Citation
Journal of Psychopharmacology, 2025, 39 (4), pp.297-300
ISSN
0269-8811
Publisher
SAGE Publications
Start Page
297
End Page
300
Journal / Book Title
Journal of Psychopharmacology
Volume
39
Issue
4
Copyright Statement
© The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39945414
Subjects
Cobenfy
KarXT
M1
M4
Schizophrenia
acetylcholine
agonist
cholinergic
clozapine
emraclidine
mechanism
muscarinic
psychosis
receptor
striatum
xanomeline
Clozapine
Antipsychotic Agents
Humans
Animals
Receptors, Muscarinic
Schizophrenia
Central Nervous System
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2025-02-13