Blockchain shows great potential to transform organization designs by enabling generalized trust to facilitate organizational coordination and control. This generalized trust replaces, fully or partially, the need for traditional coordination and control mechanisms, such as formal contracts, authority, and relational trust. Blockchain, a novel form of organizing that entwines its organizational architecture with technology, renders extreme forms of decentralization and autonomy. We conceptualize how blockchain enables generalized trust without hierarchy based on two key boundary design decisions—permeability and transparency. Taking an architectural view with a focus on information processing, we propose a typology of boundary decisions of blockchain systems and formulate propositions linking boundary decisions with the extent of generalized trust in blockchain systems. Further, we propose that complementarity among activities performed in the blockchain system amplifies a trust-enabling organization’s ability to generate generalized trust. Finally, based on the alignment of boundary decisions with goals of adoption, we present two heterogeneous and contrasting modes of adoption—actor-centric vs. technology-centric. Taken together, these two modes form the opposite ends of a continuum, offering potential adopters the flexibility of choosing from a wide range of hybrid modes.