Traffic-derived metal bioaccumulation in bone tissue as a driver of osteoporosis
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Long-term air pollution exposures, particularly to fine particulate matter, have been linked to a wide range of health issues, including cardiovascular and respiratory diseases. Recent studies have expanded this scope to include skeletal disorders, such as osteoporosis and bone fragility. This is particularly concerning given the global burden of osteoporosis, which affects 500 million people worldwide and causes 13.5 million fractures annually. While traditional air pollution sources like exhaust emissions have been extensively studied, the role of non-exhaust sources, such as brake and tyre wear, remains largely unexplored. These non-exhaust sources are becoming a critical environmental concern, especially with the adoption of heavier electric vehicles. We hypothesize that lifetime accumulation of metals from non-exhaust traffic emissions contributes to the development of osteoporosis. This hypothesis is supported by several lines of evidence: epidemiological studies showing associations between air pollution exposures and increased fracture risk, particularly in populations living near busy roads; clinical studies demonstrating metal accumulation in the bone of individuals with osteoporosis and molecular studies showing the disruptive effects of metals on bone remodeling processes, including bone formation and resorption. To investigate this further, we propose a research approach combining in vitro, in vivo, ex vivo and computational modeling techniques. By studying the effects of metals on bone cells, analyzing the impact of metal exposure in animal models and simulating long-term exposure scenarios, we aim to elucidate the mechanisms underlying air pollution-induced bone damage. This research could inform urban planning policies, vehicle design and public health interventions protecting bone health.
Date Issued
2025-07-01
Date Acceptance
2025-06-09
Citation
Medical Hypotheses, 2025, 200
ISSN
0306-9877
Publisher
Elsevier BV
Journal / Book Title
Medical Hypotheses
Volume
200
Copyright Statement
© 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
10.1016/j.mehy.2025.111687
Publication Status
Published
Article Number
111687
Date Publish Online
2025-06-10