No evidence for association between polymorphisms in GRM3 and schizophrenia
File(s)
Author(s)
Type
Journal Article
Abstract
Background
Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3.
Methods
In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples.
Results
Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns.
Conclusion
Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3.
Methods
In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples.
Results
Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns.
Conclusion
Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
Date Issued
2005-05-13
Date Acceptance
2005-05-13
Citation
BMC Psychiatry, 2005, 5
ISSN
1471-244X
Publisher
BioMed Central
Journal / Book Title
BMC Psychiatry
Volume
5
Copyright Statement
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Subjects
Adult
Case-Control Studies
European Continental Ancestry Group
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male
Polymorphism, Single Nucleotide
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate
Schizophrenia
Psychiatry
1103 Clinical Sciences
Publication Status
Published
Article Number
23