Virus-shaped mesoporous silica nanostars to improve the transport of drugs across the blood-brain barrier
Author(s)
Type
Journal Article
Abstract
Conditions affecting the brain are the second leading cause of death globally. One of the main challenges for drugs targeting brain diseases is passing the blood-brain barrier (BBB). Here, the effectiveness of mesoporous silica nanostars (MSiNSs) with two different spike lengths to cross an in vitro BBB multicellular model was evaluated and compared to spherical nanoparticles (MSiNP). A modified sol-gel single-micelle epitaxial growth was used to produce MSiNS, which showed no cytotoxicity or immunogenicity at concentrations of up to 1 μg mL-1 in peripheral blood mononuclear and neuronal cells. The nanostar MSiNS effectively penetrated the BBB model after 24 h, and MSiNS-1 with a shorter spike length (9 ± 2 nm) crossed the in vitro BBB model more rapidly than the MSiNS-2 with longer spikes (18 ± 4 nm) or spherical MSiNP at 96 h, which accumulated in the apical and basolateral sides, respectively. Molecular dynamic simulations illustrated an increase in configurational flexibility of the lipid bilayer during contact with the MSiNS, resulting in wrapping, whereas the MSiNP suppressed membrane fluctuations. This work advances an effective brain drug delivery system based on virus-like shaped MSiNS for the treatment of different brain diseases and a mechanism for their interaction with lipid bilayers.
Date Issued
2024-07-24
Date Acceptance
2024-07-01
Citation
ACS Applied Materials and Interfaces, 2024, 16 (29), pp.37623-37640
ISSN
1944-8244
Publisher
American Chemical Society
Start Page
37623
End Page
37640
Journal / Book Title
ACS Applied Materials and Interfaces
Volume
16
Issue
29
Copyright Statement
Copyright © 2024 The Authors. Published by American Chemical Society. This publication is licensed under
CC-BY 4.0.
CC-BY 4.0.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38988046
Subjects
blood–brain barrier model
brain diseases
mesoporous silica nanoparticle
molecular dynamics simulation
nanostar
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2024-07-11