A Western single-center experience with endoscopic submucosal dissection for early gastrointestinal cancers
File(s)GCAN-D-09-00074_accepted version.pdf (338.8 KB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Endoscopic Submucosal Dissection (ESD) has gained worldwide acceptance as a treatment for Early Gastrointestinal Cancers (EGICs). However, the management of these tumors in the Western world is still mainly surgical.
Our aim was to evaluate the safety and feasibility of ESD in a European center.
Based on the knowledge transferred by one of the most experienced Japanese Institutions, we conducted a pilot study on 25 consecutive patients with EGICs located in the esophagus (n=3), stomach (n=7), duodenum (n=1) and colon (n=14) at our tertiary center over a 2-year-period. Main outcome measurements were complete (R0), as were en bloc resection and management of complications.
R0 and en bloc resection rates were 100% and 84% respectively. There were 3 bleeding and 5 perforation cases. With a median follow-up of 15 months, 2 recurrences were observed.
ESD for early esophageal and gastric cancers is feasible and effective while colonic ESD requires more expertise.
Our aim was to evaluate the safety and feasibility of ESD in a European center.
Based on the knowledge transferred by one of the most experienced Japanese Institutions, we conducted a pilot study on 25 consecutive patients with EGICs located in the esophagus (n=3), stomach (n=7), duodenum (n=1) and colon (n=14) at our tertiary center over a 2-year-period. Main outcome measurements were complete (R0), as were en bloc resection and management of complications.
R0 and en bloc resection rates were 100% and 84% respectively. There were 3 bleeding and 5 perforation cases. With a median follow-up of 15 months, 2 recurrences were observed.
ESD for early esophageal and gastric cancers is feasible and effective while colonic ESD requires more expertise.
Date Issued
2010
Citation
Gastric Cancer, 2010, 2010, 13 (4), pp.258-263
ISSN
1436-3291
Publisher
Springer
Start Page
258
End Page
263
Journal / Book Title
Gastric Cancer
Volume
13
Issue
4
Copyright Statement
© 2010 by International and Japanese Gastric
Cancer Associations. Springer-Verlag Berlin Heidelberg. The final publication is available at http://link.springer.com
Cancer Associations. Springer-Verlag Berlin Heidelberg. The final publication is available at http://link.springer.com
Description
06/03/14 meb. Accepted author manuscript, OK to add.
Identifier
http://www1.imperial.ac.uk/medicine/people/s.coda/
Subjects
Gastrointestinal Neoplasms
Endoscopic Submucosal Dissection
Endoscopic Gastrointestinal Surgery
Edition
2010
Publication Status
Published
Coverage Spatial
Japan