HBF4 Catalysed Nucleophilic Substitutions of Propargylic Alcohols
File(s)EJOC_Revised.pdf (1.25 MB)
Accepted version
Author(s)
Type
Journal Article
Abstract
The activity of HBF4 (aqueous solution) as a catalyst in
propargylation reactions is presented. Diverse types of nucleophiles
were employed in order to form new C–O, C–N and C–C bonds in
technical acetone, and in air. Good to excellent yields were obtained
using low acid loading (typically 1 mol %) under simple reaction
conditions and good chemoselectivity.
propargylation reactions is presented. Diverse types of nucleophiles
were employed in order to form new C–O, C–N and C–C bonds in
technical acetone, and in air. Good to excellent yields were obtained
using low acid loading (typically 1 mol %) under simple reaction
conditions and good chemoselectivity.
Date Issued
2015-10-29
Date Acceptance
2015-10-01
Citation
European Journal of Organic Chemistry, 2015, 2015 (34), pp.7544-7549
ISSN
1434-193X
Publisher
Wiley-VCH Verlag
Start Page
7544
End Page
7549
Journal / Book Title
European Journal of Organic Chemistry
Volume
2015
Issue
34
Copyright Statement
© 2015 The Authors. Published by Wiley-VCH Verlag GmbH &Co. KGaA. This is an open access article under the terms ofthe Creative Commons Attribution License, which permits use,distribution and reproduction in any medium, provided theoriginal work is properly cited.
License URL
Sponsor
Engineering & Physical Science Research Council (EPSRC)
The Royal Society
Grant Number
EP/K030760/1
RG2015 R1
Subjects
Brønsted acid
Friedel–Crafts reaction
Homogeneous catalysis
Nucleophilic substitution
Propargylic alcohols
Organic Chemistry
0305 Organic Chemistry
0304 Medicinal And Biomolecular Chemistry
Publication Status
Published